Nuevos genes relacionados con el sistema secretor tipo 4 de Edwardsiella tarda

Noel Verjan-García; A. Carlos; Iregui Ikuo Hirono

doi:10.22579/20112629.318

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Verjan-García, N., Carlos, A., & Ikuo Hirono, I. (2015). Nuevos genes relacionados con el sistema secretor tipo 4 de Edwardsiella tarda. Orinoquia, 19(2), 186–194. https://doi.org/10.22579/20112629.318

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Publicado: Jul 1, 2015

https://doi.org/10.22579/20112629.318

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Número

Vol. 19 Núm. 2 (2015)

Sección

Ciencias de la salud

Noel Verjan-García

Department of Animal Health, Faculty of Veterinary Medicine, Universidad del Tolima, Ibagué Colombia.

A. Carlos

Universidad Nacional de Colombia, Bogotá Colombia.

Iregui Ikuo Hirono

Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato, Tokyo 108-8477, Japan

Resumen

Edwardsiella tarda es una bacteria Gram-negativa responsable de edwardsiellosis, una enfermedad de peces y mamíferos incluido el humano, la cual se caracteriza por la formación de múltiples abscesos. Distintas cepas de E. tarda poseen un número de genes asociados con virulencia, resistencia a múltiples antibióticos y sistemas secretores de toxinas que explican en cierto grado su capacidad de sobrevivir dentro de células fagocíticas y de infectar a diversos hospederos. En estudios previos, nuestro grupo secuencio parcialmente el genoma de una cepa virulenta de E. tarda (ETSJ54) aislada de lenguado japonés (Paralichthys olivaceus) con edwardsiellosis y reportó un número de genes asociados a su virulencia. En este estudio se ha re-analizado los datos de secuenciación y en este proceso se identificaron varios genes que codifican para la estructura de superficie Pili y el sistema secretor tipo IV, la mayoría de los cuales estuvieron rodeados por genes codificadores de transposasas y otros genes de origen plasmídico. La secuencia de nucleótidos de dichos genes no tuvieron identidad con la de los genes previamente reportados en E. tarda EIB202, una cepa virulenta aislada de turbot (Scophthalmus maximus) en China. Los resultados sugieren diferencias en el contenido genético de cepas de E. tarda de distinto origen geográfico y la necesidad de desarrollar nuevos proyectos de secuenciamiento de genomas de E. tarda.

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Biografía del autor/a (VER)

Noel Verjan-García, Department of Animal Health, Faculty of Veterinary Medicine, Universidad del Tolima, Ibagué Colombia.

MVZ, PhD, Immunobiology and Pathogenesis Research Group, Department of Animal Health, Faculty of Veterinary Medicine, Universidad del Tolima, Ibagué Colombia.

A. Carlos, Universidad Nacional de Colombia, Bogotá Colombia.

MV, PhD, Pathobiology Laboratory, Faculty of Veterinary Medicine, Universidad Nacional de Colombia, Bogotá Colombia.

Iregui Ikuo Hirono, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato, Tokyo 108-8477, Japan

PhD. Laboratory of Genome Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato, Tokyo 108-8477, Japan Email: [email protected]

Palabras clave:

Pathogenesis

T4SS genes

Virulence

Patogenesis

Sistema secretor tipo IV

Virulencia

Pathogenesis

T4SS genes

Virulence

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